The Science Research program is a unique offering of the Mitchell Academy of Science and Technology. Beginning in a student’s sophomore year, the program consists of three year-long parts. The purpose the Science Research program is to teach students how to do comprehensive and extensive research into a topic of their own choosing in the scientific field. The goal is for the student to learn the immersion process necessary to intensive research in a professional laboratory setting, in furtherance of an eventual entry into the Intel Science Talent Search.

Sophomores begin the program by learning how to do independent science research. They spend time searching for journal articles, learning to decipher refereed scientific literature, and finding people in the area who are involved in their field of study. Students find a mentor during the second semester, and begin working in a professional laboratory environment in the spring and summer months.

Juniors take their research a step further, working on their own hypotheses and projects with their professional mentors. They continue to meet at school, in order to fine-tune their writing and presenting skills.

Seniors finish their research, write it up into a proposal, and enter it into the Intel Science Talent Search. Intel Science Talent Search, a program of Society for Science & the Public, is America's oldest and most prestigious pre-college science competition. Every year, roughly 1,600 U.S. high school seniors enter the Intel Science Talent Search with original science projects. Forty finalists, representing the best and brightest young scientific minds in America, go on to compete for over USD 1.25 million in awards and scholarships.